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pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages for enhanced MDR reversal and chemotherapy

TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance (MDR) and as an anticancer agent for synergistic antitumor effects. However, the comparatively high critical micelle concentration (CMC), low drug loading (DL) and poor tumor target limit its further cl...

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Principais autores: Yong Xu, Shi Wang, Longshun Yang, Yuhang Dong, Yafang Zhang, Guoqing Yan, Rupei Tang
Format: Artigo
Jezik:Inglês
Izdano: KeAi Communications Co., Ltd. 2021-05-01
Serija:Asian Journal of Pharmaceutical Sciences
Teme:
Online dostop:http://www.sciencedirect.com/science/article/pii/S1818087621000143
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