Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animals

BackgroundChimeric antigen receptor (CAR) engineered natural killer (NK) cells exhibit advantages such as MHC-independent recognition and strong anti-tumor functions. However, allogeneic CAR-NK cells derived from human tissues are heterogeneous and susceptible to clearance by hosts.MethodsWe generat...

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Detaylı Bibliyografya

Asıl Yazarlar:	Qi Zhang, Chengxiang Xia, Qitong Weng, Leqiang Zhang, Yao Wang, Yanhong Liu, Xiujuan Zheng, Yunqing Lin, Yi Chen, Yiyuan Shen, Hanmeng Qi, Lijuan Liu, Yanping Zhu, Min Zhang, Dehao Huang, Fangxiao Hu, Mengyun Zhang, Hui Zeng, Jinyong Wang, Tongjie Wang
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2024-11-01
Seri Bilgileri:	Frontiers in Immunology
Konular:	embryonic stem cells CD19 CAR-NK cells hypoimmunogenicity cytotoxicity B-cell malignancy
Online Erişim:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1504459/full
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