Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality
Successful translation of chimeric antigen receptor (CAR) T cell therapy for the treatment of solid tumors has proved to be troublesome, mainly due to the complex tumor microenvironment promoting T cell dysfunction and antigen heterogeneity. Mesothelin (MSLN) has emerged as an attractive target for...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis Group
2022-12-01
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| Collection: | OncoImmunology |
| Sujets: | |
| Accès en ligne: | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2093426 |
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