Endothelial cell-secreted SPARC suppresses astrocytic CD59 expression and promotes astrocytopathy in a mouse model of neuromyelitis optica spectrum disorders

Abstract CD59 is an endogenous complement inhibitor that restricts membrane attack complex formation, protecting cells from complement-dependent cytotoxicity. Dysfunctional CD59 leads to uncontrolled complement activation and contributes to the pathogenesis of various diseases, including neuromyelit...

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Prif Awduron:	Tingting Cui, Ye Gong, Zhen Wang, Pei Li, Luhang Dai, Jia Chen, Zhe Feng, Xueli Liu, Shaogang Li, Huanyi Liu, Ke Li, Xiaoli Ding, Xiaochang Xue, Luting Yang, Lei Zhang, Rui Li, Ying Fu, Yaling Zhang, Yaping Yan
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2026-05-01
Cyfres:	Nature Communications
Mynediad Ar-lein:	https://doi.org/10.1038/s41467-026-72997-2
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