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C5a-Preactivated Neutrophils Are Critical for Autoimmune-Induced Astrocyte Dysregulation in Neuromyelitis Optica Spectrum Disorder

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune neuroinflammatory disease. In contrast to multiple sclerosis, autoantibodies against aquaporin-4 (AQP4) expressed on astrocytic end-feet have been exclusively detected in sera of NMOSD patients. Several lines of evidence suggested that...

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Principais autores: Paweł Piatek, Małgorzata Domowicz, Natalia Lewkowicz, Patrycja Przygodzka, Mariola Matysiak, Katarzyna Dzitko, Przemysław Lewkowicz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-07-01
coleção:Frontiers in Immunology
Assuntos:
astrocytes
neutrophils
complement system
glutamate
neuromyelitis optica spectrum disorder
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.01694/full
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