Targeting RAS mutants in malignancies: successes, failures, and reasons for hope

Abstract RAS genes are the most frequently mutated oncogenes and play critical roles in the development and progression of malignancies. The mutation, isoform (KRAS, HRAS, and NRAS), position, and type of substitution vary depending on the tissue types. Despite decades of developing RAS‐targeted the...

Descripció completa

Dades bibliogràfiques

Autors principals:	Hang Yang, Xinyi Zhou, Dongliang Fu, Chenqin Le, Jiafeng Wang, Quan Zhou, Xiangrui Liu, Ying Yuan, Kefeng Ding, Qian Xiao
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2023-01-01
Col·lecció:	Cancer Communications
Matèries:	RAS mutation Signal transduction RAS‐targeted therapy Combination therapy Immunotherapy Cancer metabolism
Accés en línia:	https://doi.org/10.1002/cac2.12377
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!