Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies

Abstract Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically engineered immune cells that can detect target antigens on the surface of target cells and eliminate them following adoptive transfer. Recent progress in CAR-based therapies has led to outstanding clinical...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Hamed Dabiri, Pooria Safarzadeh Kozani, Mahdi Habibi Anbouhi, Mohadeseh Mirzaee Godarzee, Mohammad Hossein Haddadi, Mohsen Basiri, Vahab Ziaei, Majid Sadeghizadeh, Ensiyeh Hajizadeh Saffar
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-07-01
Schriftenreihe:	Biomarker Research
Schlagworte:	Chimeric antigen receptor Cancer immunotherapy Genome-editing technologies Retroviral vectors Natural killer cells
Online-Zugang:	https://doi.org/10.1186/s40364-023-00509-1
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