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Human Cytomegalovirus Encodes a Novel FLT3 Receptor Ligand Necessary for Hematopoietic Cell Differentiation and Viral Reactivation

ABSTRACT The ability of human cytomegalovirus (HCMV) to reactivate from latent infection of hematopoietic progenitor cells (HPCs) is intimately linked to cellular differentiation. HCMV encodes UL7 that our group has shown is secreted from infected cells and induces angiogenesis. In this study, we sh...

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Principais autores: Lindsey B. Crawford, Jung Heon Kim, Donna Collins-McMillen, Byeong-Jae Lee, Igor Landais, Christine Held, Jay A. Nelson, Andrew D. Yurochko, Patrizia Caposio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018-05-01
Serier:mBio
Fag:
Flt3 receptor
human cytomegalovirus
hematopoiesis
pUL7
viral reactivation
Online adgang:https://journals.asm.org/doi/10.1128/mBio.00682-18
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