Burden Imposed by Heterologous Protein Production in Two Major Industrial Yeast Cell Factories: Identifying Sources and Mitigation Strategies

Production of heterologous proteins, especially biopharmaceuticals and industrial enzymes, in living cell factories consumes cellular resources. Such resources are reallocated from normal cellular processes toward production of the heterologous protein that is often of no benefit to the host cell. T...

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Detalhes bibliográficos

Principais autores:	Louise La Barbera Kastberg, Ryan Ard, Michael Krogh Jensen, Christopher T. Workman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-02-01
coleção:	Frontiers in Fungal Biology
Assuntos:	burden yeast heterologous protein production strain engineering metabolism biotechnology
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/ffunb.2022.827704/full
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