Non-Nucleoside Lycorine-Based Analogs as Potential DENV/ZIKV NS5 Dual Inhibitors: Structure-Based Virtual Screening and Chemoinformatic Analysis

Dengue (DENV) and Zika (ZIKV) virus continue to pose significant challenges globally due to their widespread prevalence and severe health implications. Given the absence of effective vaccines and specific therapeutics, targeting the highly conserved NS5 RNA-dependent RNA polymerase (RdRp) domain has...

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Detalhes bibliográficos

Principais autores:	Adrián Camilo Rodríguez-Ararat, Yasser Hayek-Orduz, Andrés-Felipe Vásquez, Felipe Sierra-Hurtado, María-Francisca Villegas-Torres, Paola A. Caicedo-Burbano, Luke E. K. Achenie, Andrés Fernando González Barrios
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-09-01
coleção:	Metabolites
Assuntos:	DENV3 ZIKV molecular docking MD simulations MM/GBSA compound library
Acesso em linha:	https://www.mdpi.com/2218-1989/14/10/519
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