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Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Targeted molecular radiation therapy is a promising emerging treatment modality in oncology, and peptide synthesis may shorten the time to reach the clinical stage. In this study, we have explored Chemo-Enzymatic Peptide Synthesis, or CEPS, as a new means of producing a therapeutic HER2 targeted Aff...

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Príomhchruthaitheoirí: Yongsheng Liu, Rezan Güler, Yunqi Liao, Anzhelika Vorobyeva, Olof Widmark, Theodorus J. Meuleman, Anna Koijen, Leendert J. van den Bos, Robert Naasz, Vitalina Bodenko, Anna Orlova, Caroline Ekblad, Vladimir Tolmachev, Fredrik Y. Frejd
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: MDPI AG 2022-11-01
Sraith:Pharmaceutics
Ábhair:
Affibody molecule
albumin binding domain (ABD)
peptide synthesis
enzymatic ligation
scaffold protein
radionuclide therapy
Rochtain ar líne:https://www.mdpi.com/1999-4923/14/11/2519
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