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Cardiac vein retroinjections provide an efficient approach for global left ventricular gene transfer with adenovirus and adeno-associated virus

Abstract Heart failure (HF) is a major burden worldwide, and new therapies are urgently needed. Gene therapy is a promising new approach to treat myocardial diseases. However, current cardiac gene delivery methods for producing global myocardial effects have been inefficient. The aim of this study w...

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Autori principali: Jaakko Lampela, Juho Pajula, Niko Järveläinen, Satu Siimes, Nihay Laham-Karam, Antti Kivelä, Isidore Mushimiyimana, Jussi Nurro, Juha Hartikainen, Seppo Ylä-Herttuala
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2024-01-01
Serie:Scientific Reports
Accesso online:https://doi.org/10.1038/s41598-024-51712-5
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