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How do pilot and feasibility studies inform randomised placebo-controlled trials in surgery? A systematic review

Introduction Randomised controlled trials (RCTs) with a placebo comparator are considered the gold standard study design when evaluating healthcare interventions. These are challenging to design and deliver in surgery. Guidance recommends pilot and feasibility work to optimise main trial design and...

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Hlavní autoři: Jane M Blazeby, David J Beard, Natalie S Blencowe, Sian Cousins, Katy Chalmers, Marion K Campbell, Alexander Gormley
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2023-11-01
Edice:BMJ Open
On-line přístup:https://bmjopen.bmj.com/content/13/11/e071094.full
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