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Rosiglitazone (BRL49653), a PPARγ-selective agonist, causes peroxisome proliferator-like liver effects in obese mice

The PPAR (peroxisome proliferator activated receptor) transcription factors are ligand-activated nuclear receptors that regulate genes involved in lipid metabolism and homeostasis. PPARα is preferentially expressed in liver and PPARγ preferentially in adipose tissue. Activation of PPARα leads to per...

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Principais autores: Ulrika Edvardsson, Monica Bergström, Maria Alexandersson, Krister Bamberg, Bengt Ljung, Björn Dahllöf
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 1999-07-01
coleção:Journal of Lipid Research
Assuntos:
BRL49653
WY14,643
peroxisome proliferation
PPAR
proteomics
ob/ob
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0022227520334799
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