MUC4 mutations promote a thrombotic phenotype in patients with paroxysmal nocturnal haemoglobinuria by increasing the deposition of terminal complement

Abstract Background Thrombosis is a common complication in paroxysmal nocturnal haemoglobinuria (PNH) patients, but primary prevention remains controversial. Identifying high‐risk individuals could enable risk‐stratified prophylactic anticoagulation strategies. Methods We analyzed clinical data from...

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Autori principali:	Yingying Chen, Mengting Che, Chaomeng Wang, Qiaoyi Bronte Zhang, Weixin Chen, Hui Liu, Chunyan Liu, Guang Sheng Ling, Rong Fu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2026-01-01
Serie:	Clinical and Translational Medicine
Soggetti:	C5b‐9 MUC4 paroxysmal nocturnal haemoglobinuria thrombosis
Accesso online:	https://doi.org/10.1002/ctm2.70567
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