Long-Term L-Glutamine Treatment Reduces Hemolysis without Ameliorating Hepatic Vaso-Occlusion and Liver Fibrosis in a Mouse Model of Sickle Cell Disease

Sickle cell disease (SCD) is an autosomal recessive monogenic disorder caused by a homozygous mutation in the β-globin gene, which leads to erythrocyte sickling, hemolysis, vaso-occlusion, and sterile inflammation. The administration of oral L-glutamine has been shown to reduce the frequency of pain...

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Principais autores:	Omika Katoch, Ramakrishna Ungalara, Tomasz Kaminski, Ziming Li, Rikesh K. Dubey, Isabella Burholt, Shweta Gudapati, Tirthadipa Pradhan-Sundd
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2023-08-01
Serija:	Biomedicines
Teme:	sickle cell disease hemolysis vaso-occlusion L-glutamine liver injury Kupffer cells
Online dostop:	https://www.mdpi.com/2227-9059/11/9/2412
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