Long-Term L-Glutamine Treatment Reduces Hemolysis without Ameliorating Hepatic Vaso-Occlusion and Liver Fibrosis in a Mouse Model of Sickle Cell Disease

Sickle cell disease (SCD) is an autosomal recessive monogenic disorder caused by a homozygous mutation in the β-globin gene, which leads to erythrocyte sickling, hemolysis, vaso-occlusion, and sterile inflammation. The administration of oral L-glutamine has been shown to reduce the frequency of pain...

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Bibliografiska uppgifter

Huvudupphov:	Omika Katoch, Ramakrishna Ungalara, Tomasz Kaminski, Ziming Li, Rikesh K. Dubey, Isabella Burholt, Shweta Gudapati, Tirthadipa Pradhan-Sundd
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2023-08-01
Serie:	Biomedicines
Ämnen:	sickle cell disease hemolysis vaso-occlusion L-glutamine liver injury Kupffer cells
Länkar:	https://www.mdpi.com/2227-9059/11/9/2412
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