Therapeutic potential of 5HT2CR in alleviating spasticity and pain via modulation of motor neurons and interneurons in spinal cord injury

Summary: Numerous adverse outcomes can be resulted in limb spasm and spasticity that occur after spinal cord injury (SCI). Here, we used adeno-associated virus (AAV) vectors and Cre-driver transgenic mice to selectively overexpress 5-hydroxytryptamine2C receptor (5HT2CR) in motor, GABAergic, and Glu...

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Autors principals:	Han Gong, Zuliyaer Talifu, Yu-Zhe Sun, Zhao-Ming Yue, Xiao-Xia Du, Liang-Jie Du
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-10-01
Col·lecció:	iScience
Matèries:	Biological sciences Natural sciences Neuroscience Sensory neuroscience
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S258900422501750X
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