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C1ql3 knockout affects microglia activation, neuronal integrity, and spontaneous behavior in Wistar rats

Abstract Background C1QL3 is widely expressed in the brain and is specifically produced by a subset of excitatory neurons. However, its function is still not clear. We established C1ql3‐deficient rats to investigate the role of C1QL3 in the brain. Methods C1ql3 knockout (KO) rats were generated usin...

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Principais autores: Li Zhang, Wei Dong, Jingwen Li, Shan Gao, Hanxuan Sheng, Qi Kong, Feifei Guan, Lianfeng Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-02-01
coleção:Animal Models and Experimental Medicine
Assuntos:
C1QL3
knockout
microglia
neuron
rat
Acesso em linha:https://doi.org/10.1002/ame2.12383
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