Synthetic promoters to induce immune-effectors into the tumor microenvironment

Greenshpan et al. explore the use of synthetic promoters based on IFNgamma, TNF alpha and hypoxia responsive elements to control gene expression. The authors describe this technology in the context of chimeric antigen expression (CAR) and propose that this method can circumvent off-target toxic effe...

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Autors principals:	Yariv Greenshpan, Omri Sharabi, Aner Ottolenghi, Avishag Cahana, Kiran Kundu, Ksenia M. Yegodayev, Moshe Elkabets, Roi Gazit, Angel Porgador
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2021-01-01
Col·lecció:	Communications Biology
Accés en línia:	https://doi.org/10.1038/s42003-021-01664-7
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