Synthetic promoters to induce immune-effectors into the tumor microenvironment
Greenshpan et al. explore the use of synthetic promoters based on IFNgamma, TNF alpha and hypoxia responsive elements to control gene expression. The authors describe this technology in the context of chimeric antigen expression (CAR) and propose that this method can circumvent off-target toxic effe...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Portfolio
2021-01-01
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| Reeks: | Communications Biology |
| Online toegang: | https://doi.org/10.1038/s42003-021-01664-7 |
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