GluN2A-mediated currents and calcium signal in human iPSC-derived neurons

Abstract Gene expression data indicate that during human brain development, neurons change the NMDA receptor (NMDAR) subunit composition to modulate their function, favouring the GluN2A subunit over GluN2B—a hallmark of neuronal maturation. However, evidence supporting this phenomenon in human iPSC-...

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Autores principales:	Sergio Escamilla, Carlos Avilés-Granados, Francisco Andrés Peralta, Ana V. Paternain, María-Ángeles Cortés-Gómez, Henrik Zetterberg, Elvira de la Peña, Federico Salas-Lucia, Javier Sáez-Valero, Inmaculada Cuchillo-Ibáñez
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Colección:	Scientific Reports
Materias:	Cerebral cortex development Neurodifferentiation NMDAR GluN2B Ro 25–6981
Acceso en línea:	https://doi.org/10.1038/s41598-026-38482-y
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