GluN2A-mediated currents and calcium signal in human iPSC-derived neurons

Abstract Gene expression data indicate that during human brain development, neurons change the NMDA receptor (NMDAR) subunit composition to modulate their function, favouring the GluN2A subunit over GluN2B—a hallmark of neuronal maturation. However, evidence supporting this phenomenon in human iPSC-...

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主要な著者:	Sergio Escamilla, Carlos Avilés-Granados, Francisco Andrés Peralta, Ana V. Paternain, María-Ángeles Cortés-Gómez, Henrik Zetterberg, Elvira de la Peña, Federico Salas-Lucia, Javier Sáez-Valero, Inmaculada Cuchillo-Ibáñez
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2026-02-01
シリーズ:	Scientific Reports
主題:	Cerebral cortex development Neurodifferentiation NMDAR GluN2B Ro 25–6981
オンライン･アクセス:	https://doi.org/10.1038/s41598-026-38482-y
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