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Fenebrutinib, a Bruton’s tyrosine kinase inhibitor, blocks distinct human microglial signaling pathways

Abstract Background Bruton’s tyrosine kinase (BTK) is an intracellular signaling enzyme that regulates B-lymphocyte and myeloid cell functions. Due to its involvement in both innate and adaptive immune compartments, BTK inhibitors have emerged as a therapeutic option in autoimmune disorders such as...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Julie Langlois, Simona Lange, Martin Ebeling, Will Macnair, Roland Schmucki, Cenxiao Li, Jonathan DeGeer, Tania J. J. Sudharshan, V. Wee Yong, Yun-An Shen, Christopher Harp, Ludovic Collin, James Keaney
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2024-10-01
Schriftenreihe:Journal of Neuroinflammation
Schlagworte:
Multiple sclerosis
Fenebrutinib
BTK
Neuroinflammation
Microglia
Organoids
Online-Zugang:https://doi.org/10.1186/s12974-024-03267-5
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