Fenebrutinib, a Bruton’s tyrosine kinase inhibitor, blocks distinct human microglial signaling pathways

Abstract Background Bruton’s tyrosine kinase (BTK) is an intracellular signaling enzyme that regulates B-lymphocyte and myeloid cell functions. Due to its involvement in both innate and adaptive immune compartments, BTK inhibitors have emerged as a therapeutic option in autoimmune disorders such as...

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Hlavní autoři:	Julie Langlois, Simona Lange, Martin Ebeling, Will Macnair, Roland Schmucki, Cenxiao Li, Jonathan DeGeer, Tania J. J. Sudharshan, V. Wee Yong, Yun-An Shen, Christopher Harp, Ludovic Collin, James Keaney
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-10-01
Edice:	Journal of Neuroinflammation
Témata:	Multiple sclerosis Fenebrutinib BTK Neuroinflammation Microglia Organoids
On-line přístup:	https://doi.org/10.1186/s12974-024-03267-5
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