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Effects of the Delta Opioid Receptor Agonist DADLE in a Novel Hypoxia-Reoxygenation Model on Human and Rat-Engineered Heart Tissue: A Pilot Study

Intermittent hypoxia and various pharmacological compounds protect the heart from ischemia reperfusion injury in experimental approaches, but the translation into clinical trials has largely failed. One reason may lie in species differences and the lack of suitable human in vitro models to test for...

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Principais autores: Sandra Funcke, Tessa R. Werner, Marc Hein, Bärbel M. Ulmer, Arne Hansen, Thomas Eschenhagen, Marc N. Hirt
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-09-01
coleção:Biomolecules
Assuntos:
3D tissue model
opioids
preconditioning
translational medicine
cardioprotection
cardiac hypertrophy
Acesso em linha:https://www.mdpi.com/2218-273X/10/9/1309
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