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Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 mutein

Single-cell RNA-seq analysis reveals that IL-2 mutein treatment expands multiple sub-states of regulatory T cells with superior suppressive function in mice. The therapeutic expansion of Foxp3 + regulatory T cells (Tregs) shows promise for treating autoimmune and inflammatory disorders. Yet, how thi...

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Autors principals: Daniel R Lu, Hao Wu, Ian Driver, Sarah Ingersoll, Sue Sohn, Songli Wang, Chi-Ming Li, Hyewon Phee
Format: Artigo
Idioma:Inglês
Publicat: Life Science Alliance LLC 2020-05-01
Col·lecció:Life Science Alliance
Accés en línia:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.201900520
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