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Medulloblastoma in Adolescents and Young Adults: Molecular Subgroups, Prognostic Biomarkers, and Age-Specific Therapeutic Challenges

Medulloblastoma is the most common malignant brain tumor in children, but it presents distinct challenges when occurring in adolescents and young adults (AYAs, aged 15–39 years). Recent molecular profiling has identified four principal medulloblastoma subgroups—WNT-activated, SHH-activated, Group 3,...

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Автори: Antonio Ruggiero, Marco Gessi, Antonio d’Amati, Alessio Albanese, Giorgio Attinà
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2026-03-01
Серія:Current Issues in Molecular Biology
Предмети:
medulloblastoma
adolescent and young adult
molecular subgroups
TP53 mutations
MYCN amplification
prognosis
Онлайн доступ:https://www.mdpi.com/1467-3045/48/3/297
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