Discovery and Characterization of a Dual-Function Peptide Derived from Bitter Gourd Seed Protein Using Two Orthogonal Bioassay-Guided Fractionations Coupled with In Silico Analysis

The hydrolysate of bitter gourd seed protein, digested by the combined gastrointestinal proteases (BGSP-GPs), exhibited the most potent inhibition on angiotensin-I-converting enzyme (ACE) with an IC₅₀ value of 48.1 ± 2.0 µg/mL. Using two independent bioassay-guided fractionations, fractio...

Descrición completa

Detalles Bibliográficos

Principais autores:	Wei-Ting Hung, Christoper Caesar Yudho Sutopo, Mei-Li Wu, Jue-Liang Hsu
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2023-11-01
Series:	Pharmaceuticals
Assuntos:	bitter gourd seeds ACE inhibitory peptide DPP4 inhibitory peptide in silico analysis LC-MS/MS
Acceso en liña:	https://www.mdpi.com/1424-8247/16/11/1629
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!