The potential of PARP inhibitors in targeted cancer therapy and immunotherapy
DNA damage response (DDR) deficiencies result in genome instability, which is one of the hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various DDR pathways, determining cell fate in the wake of DNA damage. PARPs are readily druggable and PARP inhibitors (PARPi) agains...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2022-12-01
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| Серии: | Frontiers in Molecular Biosciences |
| Предметы: | |
| Online-ссылка: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1073797/full |
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