PARP inhibition radiosensitizes BRCA1 wildtype and mutated breast cancer to proton therapy

Abstract Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that gen...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Mariam Ben Kacem, Scott J. Bright, Emma Moran, David B. Flint, David K. J. Martinus, Broderick X. Turner, Ilsa Qureshi, Rishab Kolachina, Mandira Manandhar, Poliana C. Marinello, Simona F. Shaitelman, Gabriel O. Sawakuchi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-12-01
Edice:	Scientific Reports
Témata:	DNA repair inhibitor PARP inhibitor Radiosensitization Proton therapy Radiobiology Radiotherapy
On-line přístup:	https://doi.org/10.1038/s41598-024-81914-w
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!