PARP inhibition radiosensitizes BRCA1 wildtype and mutated breast cancer to proton therapy

Abstract Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that gen...

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Auteurs principaux:	Mariam Ben Kacem, Scott J. Bright, Emma Moran, David B. Flint, David K. J. Martinus, Broderick X. Turner, Ilsa Qureshi, Rishab Kolachina, Mandira Manandhar, Poliana C. Marinello, Simona F. Shaitelman, Gabriel O. Sawakuchi
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2024-12-01
Collection:	Scientific Reports
Sujets:	DNA repair inhibitor PARP inhibitor Radiosensitization Proton therapy Radiobiology Radiotherapy
Accès en ligne:	https://doi.org/10.1038/s41598-024-81914-w
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