Benefits of group sequential design and sample size re-estimation for randomised controlled trials evaluating the prevention of ventilator-associated pneumonia: a simulation study informed by real world data

Abstract Background Ventilator-associated pneumonia (VAP) is an important healthcare acquired infection, which is associated with high morbidity and mortality. Conducting conventional randomised controlled trials (RCTs) on VAP prevention is often challenging, due to low numbers of eligible patients...

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Detalhes bibliográficos

Principais autores:	Holly Jackson, Julien Sauser, C. H. van Werkhoven, Stephan Harbarth, Marlieke E.A. de Kraker
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	BMC Medical Research Methodology
Assuntos:	Randomised clinical trial Adaptive clinical trial design Group sequential design Sample size re-estimation Ventilator-associated pneumonia
Acesso em linha:	https://doi.org/10.1186/s12874-025-02681-4
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