Rational design and in vivo validation of capsid inhibitors for enterovirus D68

Abstract Enterovirus D68 (EV-D68) is a respiratory virus that causes neurological complications such as acute flaccid myelitis (AFM) and death in children. No vaccine or antiviral is available for EV-D68. We report the structure-based design of the EV-D68 VP1 capsid inhibitors with in vivo antiviral...

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Hlavní autoři:	Kan Li, Michael J. Rudy, Thomas Klose, Haozhou Tan, Xiangmeng Wu, Hiwot A. Demssie, Jacqueline S. Anderson, Prakash Jadhav, Qing-Yu Zhang, Penny Clarke, Richard J. Kuhn, Kenneth L. Tyler, Jun Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-02-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-026-69351-x
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