Model‐guided combinatorial optimization of complex synthetic gene networks

Abstract Constructing gene circuits that satisfy quantitative performance criteria has been a long‐standing challenge in synthetic biology. Here, we show a strategy for optimizing a complex three‐gene circuit, a novel proportional miRNA biosensor, using predictive modeling to initiate a search in th...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Joerg Schreiber, Meret Arter, Nicolas Lapique, Benjamin Haefliger, Yaakov Benenson
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Springer Nature 2016-12-01
Цуврал:	Molecular Systems Biology
Нөхцлүүд:	library screening miRNA sensor modeling synthetic gene circuit
Онлайн хандалт:	https://doi.org/10.15252/msb.20167265
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!