Model‐guided combinatorial optimization of complex synthetic gene networks
Abstract Constructing gene circuits that satisfy quantitative performance criteria has been a long‐standing challenge in synthetic biology. Here, we show a strategy for optimizing a complex three‐gene circuit, a novel proportional miRNA biosensor, using predictive modeling to initiate a search in th...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer Nature
2016-12-01
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| Serie: | Molecular Systems Biology |
| Soggetti: | |
| Accesso online: | https://doi.org/10.15252/msb.20167265 |
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