MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4BDCAF13 E3 Ligase in Osteosarcoma Cells

Cullins, critical members of the cullin-RING ubiquitin ligases (CRLs), are often aberrantly expressed in different cancers. However, the underlying mechanisms regarding aberrant expression of these cullins and the specific substrates of CRLs in different cancers are mostly unknown. Here, we demonstr...

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Bibliografische Detailangaben

Hauptverfasser:	Zhi Chen, Wei Zhang, Kaibiao Jiang, Bin Chen, Kun Wang, Lifeng Lao, Canglong Hou, Fei Wang, Caiguo Zhang, Hongxing Shen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2018-03-01
Schriftenreihe:	Molecular Therapy: Nucleic Acids
Schlagworte:	miR-300 DNA methylation CUL4B CRL4B E3 ligase PTEN ubiquitination
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2162253117303098
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