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Regulation of cleavage embryo genes upon DRP1 inhibition in mouse embryonic stem cells

Dynamic-related protein 1 (DRP1) is a key protein of mitochondrial fission. In this study, we found that inhibition of activity of DRP1 led to increased levels of cleavage embryo genes in mouse embryonic stem cells (mESCs), which might reflect a transient totipotency status derived from pluripotency...

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Autors principals: Shi-Meng Guo, Yi-Ran Zhang, Bing-Xin Ma, Li-Quan Zhou, Ying Yin
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2023-05-01
Col·lecció:Frontiers in Cell and Developmental Biology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fcell.2023.1191797/full
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