Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells

Cancer stem cells drive tumor initiation, progression, and recurrence, which compromise the effectiveness of anti-tumor drugs. Here, we report that demethylzeylasteral (DML), a triterpene anti-tumor compound, suppressed tumorigenesis of liver cancer stem cells (LCSCs) by interfering with lactylation...

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Detalhes bibliográficos

Principais autores:	Lianhong Pan, Fan Feng, Jiaqin Wu, Shibing Fan, Juanjuan Han, Shunxi Wang, Li Yang, Wanqian Liu, Chunli Wang, Kang Xu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-07-01
Colecção:	Pharmacological Research
Assuntos:	Liver cancer Glycolysis Lactate Histone lactylation Tumorigenicity
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1043661822002158
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