Acitretin mitigates uroporphyrin-induced bone defects in congenital erythropoietic porphyria models

Abstract Congenital erythropoietic porphyria (CEP) is a rare genetic disorder leading to accumulation of uro/coproporphyrin-I in tissues due to inhibition of uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility, severe photosensitivity and photomutilation. Currently t...

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Autors principals:	Juliana Bragazzi Cunha, Jared S. Elenbaas, Dhiman Maitra, Ning Kuo, Rodrigo Azuero-Dajud, Allison C. Ferguson, Megan S. Griffin, Stephen I. Lentz, Jordan A. Shavit, M. Bishr Omary
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2021-05-01
Col·lecció:	Scientific Reports
Accés en línia:	https://doi.org/10.1038/s41598-021-88668-9
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