mTOR-driven integrin β4-enriched extracellular vesicles from lenvatinib-resistant hepatocellular carcinoma fuel lung metastasis via fibroblast-niche formation

Abstract Tumor-derived extracellular vesicles (EVs) play crucial roles in facilitating the colonization and growth of metastatic cancer cells in distant organs. Nevertheless, the precise mechanisms by which EVs contribute to therapy-resistant cancer dissemination remain poorly understood. In the pre...

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Bibliografische Detailangaben

Hauptverfasser:	Tiantian Zou, Xufeng Wang, Haoting Sun, Beiyuan Hu, Jianhua Li, Yu Guo, Zilu Tian, Hao Xu, Yan Zheng, Yinghan Su, Chak Lam Chan, Le Zhu, Keyu Shen, Xiaotian Shen, Qiongzhu Dong, Lun-Xiu Qin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2026-04-01
Schriftenreihe:	Signal Transduction and Targeted Therapy
Online-Zugang:	https://doi.org/10.1038/s41392-026-02625-4
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