Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction. However, it remains unclear how tumor cells can proliferate while degrading the essential amino acid Trp. Trp is...

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Principais autores:	Isabell Adam, Dyah L. Dewi, Joram Mooiweer, Ahmed Sadik, Soumya R. Mohapatra, Bianca Berdel, Melanie Keil, Jana K. Sonner, Kathrin Thedieck, Adam J. Rose, Michael Platten, Ines Heiland, Saskia Trump, Christiane A. Opitz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2018-12-01
coleção:	OncoImmunology
Assuntos:	indoleamine-2, 3-dioxygenase tryptophan-2 3-dioxygenase tumor proliferation cancer metabolism tryptophan trna synthetase immunosuppression nutrients starvation immunosurveillance inflammation and cancer
Acesso em linha:	http://dx.doi.org/10.1080/2162402X.2018.1486353
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