Tailored behavioural tests reveal early and progressive cognitive deficits in M1000 prion disease

Prion diseases are pathogenically linked to the normal cellular prion protein (PrPC) misfolding into abnormal conformers (PrPSc), with PrPSc accumulation underpinning both transmission and neurotoxicity. Despite achieving this canonical understanding, however fundamental questions remain incompletel...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Matteo Senesi, Victoria Lewis, Paul A. Adlard, David I. Finkelstein, Jee Hyun Kim, Steven J. Collins
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-05-01
coleção:	Neurobiology of Disease
Assuntos:	Prion M1000 Barnes maze Fear condition Nesting Infectious disease
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S096999612300089X
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!