Electron Leak From the Mitochondrial Electron Transport Chain Complex I at Site IQ Is Crucial for Oxygen Sensing in Rabbit and Human Ductus Arteriosus

Background As partial pressure of oxygen (pO2) rises with the first breath, the ductus arteriosus (DA) constricts, diverting blood flow to the pulmonary circulation. The DA's O2 sensor resides within smooth muscle cells. The DA smooth muscle cells’ mitochondrial electron transport chain (ETC) produc...

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Autors principals:	Austin D. Read, Rachel E. T. Bentley, Ashley Y. Martin, Jeffrey D. Mewburn, Elahe Alizadeh, Danchen Wu, Patricia D. A. Lima, Kimberly J. Dunham‐Snary, Bernard Thébaud, Willard Sharp, Stephen L. Archer
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2023-07-01
Col·lecció:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Matèries:	mitochondrial O2 sensor patent ductus arteriosus redox signaling suppressor of site IIIQ0 electron leak (S3QEL) suppressor of site IQ electron leak (S1QEL)
Accés en línia:	https://www.ahajournals.org/doi/10.1161/JAHA.122.029131
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