Efficacy of the CDK7 Inhibitor on EMT-Associated Resistance to 3rd Generation EGFR-TKIs in Non-Small Cell Lung Cancer Cell Lines

Epithelial to mesenchymal transition (EMT) is associated with resistance during EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy. Here, we investigated whether EMT is associated with acquired resistance to 3rd generation EGFR-TKIs, and we explored the effects of cyclin-dependent kinase 7 (CDK7) inh...

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Huvudupphov:	Wonjun Ji, Yun Jung Choi, Myoung-Hee Kang, Ki Jung Sung, Dong Ha Kim, Sangyong Jung, Chang-Min Choi, Jae Cheol Lee, Jin Kyung Rho
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2020-12-01
Serie:	Cells
Ämnen:	lung cancer CDK7 EGFR-TKIs EMT THZ1 resistance
Länkar:	https://www.mdpi.com/2073-4409/9/12/2596
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