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Efficacy of the CDK7 Inhibitor on EMT-Associated Resistance to 3rd Generation EGFR-TKIs in Non-Small Cell Lung Cancer Cell Lines

Epithelial to mesenchymal transition (EMT) is associated with resistance during EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy. Here, we investigated whether EMT is associated with acquired resistance to 3rd generation EGFR-TKIs, and we explored the effects of cyclin-dependent kinase 7 (CDK7) inh...

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Principais autores: Wonjun Ji, Yun Jung Choi, Myoung-Hee Kang, Ki Jung Sung, Dong Ha Kim, Sangyong Jung, Chang-Min Choi, Jae Cheol Lee, Jin Kyung Rho
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-12-01
coleção:Cells
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Acesso em linha:https://www.mdpi.com/2073-4409/9/12/2596
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