Similar deficiencies, different outcomes: succinate dehydrogenase loss in adrenal medulla vs. fibroblast cell culture models of paraganglioma

Abstract Heterozygosity for loss-of‐function alleles of the genes encoding the four subunits of succinate dehydrogenase (SDHA, SDHB, SDHC, SDHD), as well as the SDHAF2 assembly factor predispose affected individuals to pheochromocytoma and paraganglioma (PPGL), two rare neuroendocrine tumors that ar...

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Hlavní autoři:	Fatimah J. Al Khazal, Sanjana Mahadev Bhat, Yuxiang Zhu, Cristina M. de Araujo Correia, Sherry X. Zhou, Brandon A. Wilbanks, Clifford D. Folmes, Gary C. Sieck, Judith Favier, L. James Maher
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-12-01
Edice:	Cancer & Metabolism
Témata:	Succinate dehydrogenase Pheochromocytoma Paraganglioma Tricarboxylic acid cycle Hypoxia Complex I
On-line přístup:	https://doi.org/10.1186/s40170-024-00369-9
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