Similar deficiencies, different outcomes: succinate dehydrogenase loss in adrenal medulla vs. fibroblast cell culture models of paraganglioma

Abstract Heterozygosity for loss-of‐function alleles of the genes encoding the four subunits of succinate dehydrogenase (SDHA, SDHB, SDHC, SDHD), as well as the SDHAF2 assembly factor predispose affected individuals to pheochromocytoma and paraganglioma (PPGL), two rare neuroendocrine tumors that ar...

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Principais autores:	Fatimah J. Al Khazal, Sanjana Mahadev Bhat, Yuxiang Zhu, Cristina M. de Araujo Correia, Sherry X. Zhou, Brandon A. Wilbanks, Clifford D. Folmes, Gary C. Sieck, Judith Favier, L. James Maher
格式:	Artigo
語言:	Inglês
出版:	BMC 2024-12-01
叢編:	Cancer & Metabolism
主題:	Succinate dehydrogenase Pheochromocytoma Paraganglioma Tricarboxylic acid cycle Hypoxia Complex I
在線閱讀:	https://doi.org/10.1186/s40170-024-00369-9
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