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Sir proteins impede, but do not prevent, access to silent chromatin in living Saccharomyces cerevisiae

Abstract Gene silencing at the mating-type loci in budding yeast (HMRa and HMLα) depends on the Sir proteins. Sir2, Sir3 and Sir4 are indispensable, whereas Sir1 has a limited role. Sir proteins are also involved in repression at telomeres and rDNA repeats. Sir proteins may mediate silencing by limi...

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Bibliografische gegevens
Hoofdauteurs: Kenneth Y. Wu, Zhuwei Xu, Hemant K. Prajapati, Peter R. Eriksson, David J. Clark
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2026-04-01
Reeks:Scientific Reports
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Online toegang:https://doi.org/10.1038/s41598-026-44518-0
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