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Quantitative evaluation of genotoxicity data for risk assessment and regulatory decision-making: Time for a paradigm shift

Genotoxicity plays an important role in chemical safety assessment, as genetic alterations can lead to severe and irreversible health consequences. To date, the assessment of genotoxicity has mostly been limited to hazard identification, followed by rigorous risk mitigation measures if a substance i...

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Автори: Benjamin Sachse, Sebastian Schmeisser, Jan van Benthem, Raffaella Corvi, Eugenia Dogliotti, Norman Ertych, Roland Frötschl, Ulrike Gündel, Kristin Herrmann, George Johnson, Carsten Kneuer, Jeannette König, Hans-Jörg Martus, Stefan Pfuhler, Stephanie Smith-Roe, Helga Stopper, Paul White, Tanja Schwerdtle, Andreas Hensel, Tewes Tralau
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2026-02-01
Серія:Environment International
Предмети:
Genotoxicity
Mutagenicity
Quantitative approach
Regulatory toxicology
Risk assessment
Symposium
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S0160412026000280
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